Lu-177-Based Peptide Receptor Radionuclide Therapy for Advanced Neuroendocrine Tumors

Structures and chelators of PRRT for radiolabeling based on octapeptides such as octreotide (a), octreotate (b), DOTA-TOC (c), DOTA-TATE (d), and Lu-177-DOTA-TATE (e). According to the structure of Lu-177-labeled DOTA-TATE, DOTA is a chelator for the coupling of the Lu-177 and the somatostatin analogue (e