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- 2019
Original research article: Increased levels of sST2 in patients with mitral annulus disjunction and ventricular arrhythmiasDOI: 10.1136/openhrt-2019-001016 Keywords: mitral annulus disjunction, arrhythmia, biomarker, sST2 Abstract: Displacement of the mitral valve, mitral annulus disjunction (MAD), is described as a possible aetiology of sudden cardiac death. Stress-induced fibrosis in the mitral valve apparatus has been suggested as the underlying mechanism. We aimed to explore the association between stretch-related and fibrosis-related biomarkers and ventricular arrhythmias in MAD. We hypothesised that soluble suppression of tumourigenicity-2 (sST2) and transforming growth factor-β1 (TGFβ1) are markers of ventricular arrhythmias in patients with MAD
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