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- 2018
DNA Methylation in Osteoarthritis: Current Status and Therapeutic ImplicationsDOI: 10.2174/1874312901812010037 Keywords: Osteoarthritis, Epigenetics, DNA, Methylation, Cartilage, Chondrocyte Abstract: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors are strongly associated with its development; however, recently it has been observed that epigenetic modifications are also involved in the pathogenesis of OA. DNA methylation is related to gene silencing, and several studies have investigated its role in the loci of different pathways or molecules associated to OA
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