Lipidized prolactin-releasing peptide improved glucose tolerance in metabolic syndrome: Koletsky and spontaneously hypertensive rat study

The SHROB (n？=？16) and SHR (n？=？16) were purchased at the age of 6 weeks. Before the start of treatment fasted blood plasma samples were collected from the tail vessels at the age of 16 weeks for determination of the basic biochemical plasma profile. Dosing period started at the age of 16 weeks. palm11-PrRP31 was applied intraperitoneally to SHR and SHROB (n？=？8) at a dose of 5？mg/kg once a day for 21 days. At the end of the experiment rats were overnight fasted, blood samples from the tail vessels were collected for determination of the biochemical plasma parameters, and then the oral glucose tolerance test was performed. Thereafter, arterial blood pressure was measured. The animals were killed by decapitation and tissue samples were collecte