A recombinant vesicular stomatitis-based Lassa fever vaccine elicits rapid and long-term protection from lethal Lassa virus infection in guinea pigs

Rapid protection from lethal Lassa virus challenge with a single dose of VSVΔG-LASVGPC vaccine. a Survival, weight loss (inset) and b temperature analysis of Hartley guinea pigs challenged 14 and 7 days post-vaccination (n？=？6). c Survival, weight loss (inset) and d temperature analysis of Harley guinea pigs challenged 25 days post-vaccination (n？=？6). Mantel-Cox survival analysis was used and all data are presented as mean values with error bars indicating SEM. p？=？0.1234 (ns), 0.0332 (*), 0.0021 (**), 0.0002 (***), <0.0001 (****