Role of innate lymphoid cells and dendritic cells in intradermal immunization of the enterovirus antigen

EV71 and CA16 antigen distribution in various tissues and pathological features. Immunohistochemical observation of the EV71 and CA16 antigens after administration via a intradermal (ID) and b intramuscular (IM) routes at 12？h and 24？h post inoculation. c EV71 viral RNA and d CA16 viral RNA in local tissues of three groups. Pathological observation of e intradermal (ID) tissues and f intramuscular (IM) tissues. Scale bar is 100？μm. Data are representatives of three independent experiments (error bars represent SD).; Statistical significance were assessed by unpaired t tests (*p？<？0.01, **p？<？0.001