Obesity and Brain Positron Emission Tomography

Brain areas involved in the regulation of eating behavior: amygdala (behavioral salience and stress responses), anterior cingulate cortex (regulation of autonomic function of the body, reward anticipation, and decision making), brainstem (blood–brain barrier crossing of peripheral peptide hormones and binding to intracerebral receptors), dorsolateral prefrontal cortex (goal-directed behavior), fusiform gyrus (visual association cortex), hypothalamus (integration of homoeostatic information from the body), insula (interoception, homoeostasis, and integration of sensory signals across modalities), nucleus accumbens (reward prediction and conditioning), nucleus caudatus (feedback processing), and the orbitofrontal cortex (valuation and secondary gustatory cortex). Reprinted from Functional neuroimaging in obesity and the potential for development of novel treatments, Lancet Diabetes Endocrinology, 4(8), Schl？gl H et al., 695–705, 2016, with permission from Elsevie