Human papillomavirus 16 sub-lineage dispersal and cervical cancer risk worldwide: Whole viral genome sequences from 7116 HPV16-positive women

DOI: 10.1016/j.pvr.2019.02.001

Keywords: ADC, adenocarcinoma/adenosquamous cell carcinoma, ASCUS, atypical squamous cells of undetermined significance, CI, confidence interval, CIN, cervical intraepithelial neoplasia, HPV, human papillomavirus, HC2, Hybrid Capture2, HSIL, high-grade squamous intraepithelial lesion, IARC, International Agency for Research on Cancer, ICO, Catalan Institute of Oncology, KPNC, Kaiser Permanente Northern California, LSIL, low-grade squamous intraepithelial lesion, NCI, National Cancer Institute, OR, odds ratio, SCC, squamous cell carcinoma HPV16, Cervical cancer, HPV carcinogenesis, HPV epidemiology, HPV genomics, Whole virus genome sequencing

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Abstract:

Human papillomavirus (HPV)16 can be separated into genetic sub-lineages (A1–4, B1–4, C1–4, D1–4) which may have differential cervical cancer risk

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