Immunotherapy for HPV associated cancer

Future immunotherapy using a holistic approach to treat HPV associated disease combining optimized traditional therapy (radio-chemotherapy) with antigen specific vaccination, immune- and tumour modulation. Abbreviations: HPV, human papillomavirus; CAR, chimeric antigen receptor; DAMP, danger associated molecular patterns; TLR, toll like receptor; DC, dendritic cell; EGFR, endothelial growth factor receptor; VEGF, vascular endothelial growth factor; VLP, virus like particle; STING, stimulator of interferon genes; mTOR, mechanistic target of rapamycin; CDK, cyclin dependent kinase; RT, radio therapy