AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination

AATYK is up-regulated in differentiating OLs. A–F Sections of spinal cord from E16.5, E18.5, P4, P7, P15, and P30 mice subjected to ISH with AATYK riboprobe. Expression of AATYK started at？~ E18.5 in the spinal white matter. Its expression progressively increased between E18.5 and P7, and then was scattered throughout the cord at P15. By P30, AATYK expression had gradually decreased in the white matter and was detectable in the gray matter. Arrows indicate white matter cells; arrowheads indicate gray matter cells. G AATYK-expressing cells immunoreactive to Olig2 in the corpus callosum at P15. H–I The numbers of AATYK+ cells were reduced drastically in Myrf CKO mice at P3. Arrows indicate white matter cells; arrowheads indicate AATYK+ Olig2+ double-positive cells. Scale bars, 50 μm