Successful application of prime and pull strategy for a therapeutic HSV vaccine

Recurrent Lesion Scores. In study 1, HSV-2 infected animals were either vaccinated with trivalent vaccine, treated Ivag/topical with imiquimod, both or neither as described in the methods. Animals were then followed daily for recurrent lesions from day 15–70. a shows the cumulative recurrent lesion scores over the time period of day 15–70. b shows the total recurrent lesion score from the day after the first immunization (day 15) until day 70. c shows total recurrent lesion score from the day after the third immunization (day 43) until day 70. The numbers above the bars are the number of animals with recurrent lesion/total number of animals ap？<？0.05 vs PBS; bp？<？0.001 vs vaccine alone group cP？<？0.001 vs. PBS and P？<？0.01 vs the vaccine alone group comparing mean lesion score