Conceived and designed the experiments: MH and MM. Performed the experiments: X-LW. Analyzed the data: X-LW, JI, L-JM, KT, HN, H-YB, B-SS, HK-n, MK, TC, TY and AH. Contributed reagents/materials/analysis tools: JI, L-JM and KT. Wrote the paper: X-LW and MH
