The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression

PPM1A is underexpressed in ER-negative breast cancer and correlates with poor survival. a PPM1A is underexpressed in ER-negative breast cancer compared to ER-positive breast cancer in eight publically available datasets. Center lines show median, whiskers represent 95% confidence intervals, and dashes indicate maximum and minimum values. p-values were calculated using Student’s t-test (****p？<？0.0001). b Low PPM1A expression correlates with poor survival. Kaplan–Meier curves were generated from the van de Vijver dataset, showing overall survival of all breast cancer (n？=？295), ER-positive (n？=？266), and ER-negative (n？=？69) patients. High and low expression groups were dichotomized by median PPM1A expression in each group. Curve comparisons of stratified groups were calculated using the Mantel-Cox log-rank test, with p？<？0.05 being considered statistically significan