Emerging Tracers for Nuclear Cardiac PET Imaging

Schematic structure of radioisotope-labeled tetraphenylphosphonium cation derivatives. a (4-[18F]fluorophenyl)triphenylphosphonium cation ([18F]TPP), b (3-[18F]fluoropropyl)triphenylphosphonium cation, c (5-[18F]fluoropentyl)triphenylphosphonium cation ([18F]FPTP), d (6-[18F]fluorohexyl)triphenylphosphonium cation ([18F]FHxTP), e (7-[18F]fluoroheptyl)triphenylphosphonium cation ([18F]FHtTP), f (8-[18F]fluorooctyl)triphenylphosphonium cation ([18F]FOTP), g (2-(2-[18F]fluoroethoxy)ethyl)triphenylphosphonium cation ([18F]FETP), h (2-(2-[18F]fluoroethoxy)ethyl)tris(4-methoxyphenyl)phosphonium cation ([18F]FETMP), i (4-[18F]fluorobenzyl)triphenylphosphonium cation ([18F]FBnTP), j (4-(2-(2-(2-[18F]fluoroethoxy)ethoxy)ethoxy)benzyl)triphenylphosphonium cation ([18F]FPEGBnTP), k tris(4-(dimethylamino)phenyl)(4-[18F]fluorobenzyl)phosphonium cation, l (4-([18F]fluoromethyl)benzyl)triphenylphosphonium cation ([18F]FMBTP), m (3-([18F]fluoromethyl)benzyl)triphenylphosphonium cation ([18F]mFMBTP), n (4-([18F]fluoromethyl)benzyl)tris(2-methoxyphenyl)phosphonium cation, o (4-([18F]fluoromethyl)benzyl)tris(3-methoxyphenyl)phosphonium cation, p (4-([18F]fluoromethyl)benzyl)tris(4-methoxyphenyl)phosphonium cation, q tris(4-tert-butylphenyl)(2-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)ethyl)phosphonium cation (18F]MitoPhos_04) r (2-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)ethyl)trip-tolylphosphonium cation (18F]MitoPhos_05), s tris(3,5-dimethylphenyl)(2-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)ethyl)phosphonium cation ([18F]MitoPhos_07