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OALib Journal期刊
ISSN: 2333-9721
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-  2018 

RpbL12 Assists Catalysis by Correctly Positioning the Incoming Aminoacyl-tRNA in the A-Site of E. coli 70S Ribosomes

DOI: 10.2174/1874091X01812010113

Keywords: E. coli ribosomal protein bL12, GGQ-like GAN motif of bL12, Lys-65 of bL12, Site-directed mutagenesis, Mechanism of peptide bond formation, Aminoacyl-tRNA

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Abstract:

We have recently demonstrated that Lys-65 of the 62GANK65 motif of E. coli RpbL12 was affinity labeled with a tRNA analogue, resulting in the loss of activity

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