Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat

Incubation with paraquat？+？lectin increases the rate of α-synuclein fibrillation. a Time course of α-synuclein fibrillation in the presence of α-synuclein alone (white, α-syn, n？=？6), paraquat (light gray, P, n？=？7), lectin (dark gray, L, n？=？4) or a combination of paraquat？+？lectin (black, P？+？L, n？=？6). b Graphic summary of fibrillation t1/2 for α-synuclein. *p？<？0.05 vs. α-synuclein alone; #p？<？0.05 vs. paraquat or lecti