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- 2019
Dysregulation of microRNA metabolism in motor neuron diseases: Novel biomarkers and potential therapeuticsDOI: 10.1016/j.ncrna.2018.12.001 Keywords: Motor neuron diseases, microRNAs, RNA therapeutics Abstract: In the last 15 years, several classes of small regulatory RNAs have been identified, uncovering the widespread impact of non-coding elements in the human genome on cell homeostasis and human diseases. MicroRNAs (miRNAs) are a family of small, non-coding RNAs, which exert silencing of mRNA targets in a sequence-dependent fashion. Many miRNAs are specifically expressed in the central nervous system, where they display roles in differentiation, neuronal survival, neuronal plasticity and learning. On the other hand, deregulated miRNA/mRNA expression networks are deeply involved in neurodegeneration
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