Differential contributions of subthalamic beta rhythms and 1/f broadband activity to motor symptoms in Parkinson’s disease

Effects of electrophysiological broadband activity on the estimation of beta activity. a Examples of simulated data representing how the 1/f broadband activity can lead to incorrect estimations of pathological beta rhythms. b Examples of how the estimation of beta changes when the broadband activity is small (i and iii) or large (ii). c Mathematical modeling of broadband activity and beta activity, together with the parameters estimated. The panel depicts the actual fitting from patient 5 (left hemisphere); the other model fits to individual patients are reported in Supplementary Figure 1. d Effect of changing one parameter on the broadband activity (top panel) and beta activity (bottom panel) functions; light color？=？small parameter value, neutral color？=？intermediate parameter value, dark color？=？large parameter value. See Supplementary Methods for detail