SDH-deficient renal cell carcinoma associated with biallelic mutation in succinate dehydrogenase A: comprehensive genetic profiling and its relation to therapy response

Tumor morphology and IHC results as discussed in the text. Pseudo-papillae and perivascular pseudo-rosettes (a–c), papillae (d), solid foci and papillae (e), microcysts (f), spindle cell foci and pseudo-papillae (g), pure spindle cell areas (h), eosinophilic cytoplasmic inclusions (arrows in i). Immunohistochemical analysis demonstrates negative staining for SDHA (j) and SDHB (k). Internal controls show SDHA and SDHB staining in nonneoplastic tissu