Utility of the JAX Clinical Knowledgebase in capture and assessment of complex genomic cancer data

The JAX-CKB complex molecular profile. a Structure of the relationship between the complex molecular profile (top) and therapy response, via the molecular profile response. b Example of a molecular profile response associated with a complex profile. This complex molecular profile comprises two alterations: EGFR E746_A750del and MET amplification, which was demonstrated in a clinical study (evidence source) to be resistant (response type) to Osimertinib (therapy) in a lung adenocarcinoma (tumor type) patien