Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress

Short exposure to H2O2 induces a decrease of population doubling in a dose-dependent manner, but does not affect the cell viability in HEI-OC1 cells. a Population doubling time. Population doubling experiments were performed in duplicate. b Cell viability. Cell viability was determined by trypan blue staining at the indicated times after short exposure (1？h) with H2O2 (0？μM, 100？μM, 300？μM, and 1？mM). All values are showed as mean？±？SD from three or more independent studies, n？=？6 per group. *P？<？0.0