Caveolin-1 as a pathophysiological factor and target in psoriasis

Spatiotemporal interaction of the skin and underlying dermal WAT (dWAT) in psoriasis: a normal non-psoriatic skin; b modification of the dWAT located beneath the future psoriatic lesion leading to a stable local reduction of Cav-1 content in this tissue and inflammation in this area (Cav-1 expression in the covering skin is normal); c to compensate this Cav-1 reduction in dWAT, exosomes start to transport Cav-1 from the skin to dWAT which appears as a sink for Cav-1; d this exosomal transport (outflow) is not able to compensate for the strong deficiency of Cav-1 in dWAT; instead, it causes continuous reduction of Cav-1 in the skin and, consequently, its inflammatory state and hyperproliferatio