The role of PANSS symptoms and adverse events in explaining the effects of paliperidone on social functioning: a causal mediation analysis approach

Direct acyclic graph representing the potential role of PANSS symptoms, weight gain (WG), and extrapyramidal symptoms measured via the Simpson–Angus Scale (SAS) as mediators of the effect of paliperidone on social functioning measured by PSP scores. Despite the randomization at the treatment level, this model requires taking into account potential confounders of the mediator-outcome associatio