pAKT pathway activation is associated with PIK3CA mutations and good prognosis in luminal breast cancer in contrast to p-mTOR pathway activation

pAKT and p-mTOR signatures derived from the TCGA. a Venn diagram shows no intersection between the pAKT and p-mTOR gene signatures. b Network representation of the gene signatures. Each node represents the genes up-regulated or down-regulated in the signature. Edges show signatures sharing a significant number of genes. Network clustering shows the tendency of these signatures to cluster together according to their proliferation status. c Integrated analysis of the PIK3CA/pAKT/m-TOR pathway in the TCGA. Luminal breast cancer subtypes differ by pAKT and p-mTOR activity. The panel includes a protein-based (RPPA) proteomic status. Tumors were ordered first by mRNA subtype (luminal A versus B). P values were calculated using the Mann–Whitney tes