An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites

Schematic representation of PAS switches. Switches in PAS utilization are shown with arrows: upstream switches are depicted in blue and downstream switches in red. An upstream switch is most often from distal 3′-UTR to any internal gene regions (intron, exon, and internal 3′-UTR), and a downstream switch is most often from any internal gene regions to distal 3′-UTR. Switches between tandem PASs in the distal 3′-UTR are also shown. The most prominent switches are depicted with continues line. PASs are depicted with vertical bars, the gene regions, exon (E), intron (I), and 3′-UTR are indicated. Illustrated are the most abundant switch possibilitie