Sustained release of decorin to the surface of the eye enables scarless corneal regeneration

Processing and intrinsic material properties of the gellan-based fluid gel eye drop. a Schematic showing the production of the fluid gel: where the initial sol is continuously processed under shear whilst being cooled to form “ribbon-like” gelled entities shown using (i) transmission microscopy and (ii) scanning electron microscopy. b Time-dependent viscosity profiles obtained for the gellan eye drop, highlighting a degree of thixotropy. c The fluid gel being dispensed from the eye dropper packaging (gel has been stained blue so as to be visible in the photograph). d Small deformation rheology data obtained at a single frequency (1？Hz, 0.5% strain) as a function of time. Data show the evolution of an elastic network post-shearing resulting in a transition from liquid to solid-like behavior. e Anterior segment OCT images showing the ocular surface before fluid gel application (top image) and post application (bottom image). Images demonstrate a uniform layer that covers the entirety of the ocular surfac