Effects of maternal inhalation of carbon black nanoparticles on reproductive and fertility parameters in a four-generation study of male mice

Time mated female NMRI were exposed via whole body inhalation to 4.6 and 37？mg/m3 of CB Printex 90 or HEPA-filtered clean air for 45？min a day from gestation day 4 to 18. The male germ line was mated with na？ve females for four generations. The female germ line was mated with na？ve males for 2 generations. For the fourth generation, only offspring from the clean air and the high dose (37？mg/m3) groups were analyse