Quantitative biokinetics over a 28？day period of freshly generated, pristine, 20 nm titanium dioxide nanoparticle aerosols in healthy adult rats after a single two-hour inhalation exposure

DOI: 10.1186/s12989-019-0303-7

Keywords: Spark ignition generated titanium dioxide nanoparticle aerosols, Characterization of physicochemical particle properties, Intratracheal inhalation of freshly generated aerosols, Translocation across air-blood-barrier, Accumulation in secondary organs and tissues, Long-term alveolar macrophage-mediated nanoparticle clearance, Nanoparticle relocation into the interstitium, Re-entrainment from interstitium back to lung epithelium for clearance towards the larynx

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