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- 2018
Early and Late Histological and Ultrastructural Findings in Resected Infantile Capillary Hemangiomas Following Treatment with Topical Beta-Blocker Timolol Maleate 0.5%DOI: 10.1159/000477411 Keywords: Infantile capillary hemangioma, Topical β-blocker, Topical timolol maleate 0.5% Abstract: Infantile capillary hemangiomas (IHs) affect approximately 4–5% of infants. The systemic nonselective β-adrenergic antagonist, propranolol, has become the standard first-line treatment for severe IHs. The topical β-antagonist, timolol maleate, has also demonstrated efficacy and safety in treating superficial and some deep capillary hemangiomas. Despite their therapeutic success and prevalent use, the mechanism of action of β-adrenergic antagonists in the treatment of IHs is not well understood
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