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- 2017
Scaffolding proteins in the development and maintenance of the epidermal permeability barrierDOI: 10.1080/21688370.2017.1341969 Keywords: cadherins, claudins, desmosomes, epidermal permeability barrier, occludin, tight junctions, transepithelial resistance, transepidermal water loss Abstract: The skin of mammals and other terrestrial vertebrates protects the organism against the external environment, preventing heat, water and electrolyte loss, as well as entry of chemicals and pathogens. Impairments in the epidermal permeability barrier function are associated with the genesis and/or progression of a variety of pathological conditions, including genetic inflammatory diseases, microbial and viral infections, and photodamage induced by UV radiation
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