In Situ Cross-Linkable Hydrogels as a Dynamic Matrix for Tissue Regenerative Medicine

Cross-linking strategies to fabricate in situ forming hydrogels. In situ cross-linkable hydrogels exhibit phase transition from solution to gel state through physical and chemical cross-linking reactions. These advanced hydrogel materials can serve as dynamic cellular or acellular matrices for tissue engineering and regenerative medicine. Abbreviations: GelMA, gelatin-methacryloyl; GH, gelatin-g-hydroxyphenyl propionic acid; HRP, horseradish peroxidase; GtnFA, gelatin-g-ferulic acid; Lac, laccase; CD-HA, b-cyclodextrin-conjugated hyaluronic acid; AD-HA; adamantine-modified hyaluronic aci