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- 2016
Probing and rearranging the transcription factor network controlling the C. elegans endodermDOI: 10.1080/21624054.2016.1198869 Keywords: C. elegans, ELT-2, ELT-7, END-1, END-3, GATA factor, gene regulation, intestine, transcription Abstract: The ELT-2 GATA factor is the predominant transcription factor regulating gene expression in the C. elegans intestine, following endoderm specification. We comment on our previous study (Wiesenfahrt et al., 2016) that investigated how the elt-2 gene is controlled by END-1, END-3 and ELT-7, the 3 endoderm specific GATA factors that lie upstream in the regulatory hierarchy. We also discuss the unexpected result that ELT-2, if expressed sufficiently early and at sufficiently high levels, can specify the C. elegans endoderm, replacing the normal functions of END-1 and END-3
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