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- 2017
Understanding Hepatitis C Virus Drug Resistance: Clinical Implications for Current and Future RegimensKeywords: hepatitis C virus, HCV, resistance, resistance-associated substitution, RAS, mutations, HCV treatment, HCV retreatment, direct-acting antiviral, NS5A Abstract: Viral resistance to direct-acting antiviral drugs may impact their effectiveness during treatment of hepatitis C virus (HCV) infection. Most data on HCV drug resistance concern genotypes 1 and 3. The clinical impact of resistance to HCV nonstructural protein 5A (NS5A) inhibitors and a practical approach to indications and methods for resistance testing are discussed
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