Combination of Mesenchymal Stem Cells, Cartilage Pellet and Bioscaffold Supported Cartilage Regeneration of a Full Thickness Articular Surface Defect in Rabbits

Diagrammatic representation showing the in vivo experimental design in knee joints of NZW rabbits of full thickness surgical ablation of the tibial articular surface. A Control rabbit that received no treatment; B BM-MSCs (1 × 106 cells)？+？Hyalofast？; C cartilage pellet (CP)？+？Hyalofast？; and D BM-MSCs (1 × 106 cells)？+？CP？+？Hyalofast？. A, B showed partial to moderate filling with persistence of the surgical defect. C, D showed good tissue regeneration with near complete filling of the surgical defect. *NZW: New Zealand white, BM-MSCs: bone marrow mesenchymal stem cell