Analyses of IL-6, IL-10, IL-17A, INF-γ and TNF-α Cytokines in Diseases of Mucopolysaccharidosis Type I and Mucopolysaccharidoses Type VI

Background: Mucopolysaccharidoses (MPS) are a group of lysosomal storage diseases, which are caused by the deficiency of one of the enzymes essential for the catabolism of Glycosaminoglycans. Seven different types of MPS have already been identified, and some are classified into subtypes depending on which enzyme is deficient as correlated to clinical findings. This article aims to evaluate some cytokines in order to understand the immunological relationship in plasma samples of patients with MPS type I (MPS I) and in leukocyte samples of patients with MPS type VI (MPS VI) by comparing healthy individual controls. Methods: 28 subjects (MPS I = 7, healthy controls = 7 and MPS VI = 7; healthy controls = 7) as well as dosages of IL-6, IL-10, IL-17A and TNF-α which were determined by ELISA. Results: In both comparisons that were performed, TNF-α levels were different among MPS I and MPS VI individuals when compared to healthy controls, suggesting that this cytokine could be a potential inflammatory marker for disease monitoring. On the other hand, IL-17A showed a negative correlation with IL-6 only in individuals with MPS VI, confirming the variability of multi-systemic symptoms of this disease. Conclusions: The results presented in this article show a relationship between human genetics and immunology, trying to monitor different stages of life of patients with these diseases, in order to improve their quality of life. The analysis of the cytokine profile is very important in the evaluation of the relation between diseases and their systemic effects