Pharmacological Aspects of Solasodine Found in Solanum xanthocarpum and khasianum: A Review

Epilepsy is a neurological disorder (related to central nervous system) in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations, and sometimes loss of awareness. Epilepsy is considered to be resolved for everyone who is seizure-free for the last 10 years out of which 5 years should be without medicines. Although lots of antiepileptic drugs are available in the market, almost 33% patients continue to present seizure. For the curing of epilepsy disorder there are some medicinal plants such as a Ficus sycomorus, Sclerocaryabirrea, Annona diversifolia, and plants from Solanaceae family, and many more used in traditional medicine have found with anticonvulsant properties in animal models and may be a great and novel source of newer antiepileptic drugs. Based on various reviews on Solanaceae plants eg. Solanum nigrum also consists the active constituent of solasodine and it is the main constituent to inhibit the epilepsy disorder by the exhibition of excitatory sodium voltage channels they are responsible for excitation of neurons. It should be very helpful to continuing research on Solanaceae plants especially those contain solasodine because it helps further curing treatment about epilepsy disorder