Immobilization Stress-Induced Alterations of Monoamines in Brain of the Rat

Monoaminergic systems are important modulators of the responses to stress and stress may influence feeding behavior, and the involvement of monoamines in the control of food intake is well to recognize and other functions. This paper is focusing on using animal models as a stress model, a forced swimming stress was applied to rats and causes a characteristic behavioral change such as an immobile posture, was recognized. We studied the effects of acute stress on levels of 5-hydroxytryptamine (5-HT), histamine (His), gamma aminobutyric acid (GABA) and glutamate (Glu) in different parts of the stress and non-stress rat brain. This stress affected the brain monoamine levels significantly. These results suggest that alterations in levels of brain monoamines after acute immobilization force swim stress are associated with several neurodegenerative and neuropsychiatric diseases and it is capable of altering physiological homeostasis of the body. Keywords: Forced-swimming stress mode; Brain monoamines; 5-HT, GABA; Glutamate; Histamin