Immunohistochemical Study on Hormone Receptors and HER2 Status in Invasive Breast Carcinoma and its Therapeutic Implications

Background: Immunohistochemistry (IHC) has become an integral part of histopathology in the diagnosis of biopsysample. Although haematoxylin and eosin (H & E) stain remains the fundamental basis for diagnostic pathology of thebreast, IHC stains provide useful and sometimes vital information. Moreover, the role of hormonal therapy in hormonereceptor–positive breast tumours, as well as targeted chemotherapeutic agents for human epidermal growth factorreceptor-2 (HER2) positive cases, IHC studies represent a major part of workups