Pyoderma Gangrenosum : An enigma without a cure?

Pyoderma Gangrenosum (PG) is a rare, chronic, recurrent distinctive cutaneous ulceration which is usually idiopathic,but may be associated with systemic diseases in at least 50% of patients who are affected. The diagnosis is made byexcluding other causes of similar-appearing cutaneous ulcerations, including infection, malignancy, vasculitis,collagen vascular diseases, diabetes and trauma. The etiopathogenesis of PG is still not well understood. Clinically, itis classified into ulcerative, pustular, bullous and vegetative types. A few atypical and rare variants have also beendescribed. The diagnosis mainly depends on the recognition of evolving clinical features as investigations only assistin the diagnosis. Therapy for pyoderma gangrenosum involves the use of anti-inflammatory agents, includingantibiotics, corticosteroids, immunosuppressive and biologic agents