Intragastric sensitization to peanut in the absence of a Th2-skewing adjuvant in mice genetically predisposed to food allergy

Recently, we identified a Collaborative Cross mouse strain (CC027) that is orally reactive to peanut following sensitization with peanut plus cholera toxin. Interestingly, these mice were found to produce detectable levels of peanut-specific IgE before sensitization with peanut and cholera toxin. Accordingly, we aimed to determine whether CC027 mice could be sensitized to peanut without the use of any adjuvant.