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- 2019
Characterizing drug-induced capillary leak syndromes using the World Health Organization VigiBaseDOI: 10.1016/j.jaci.2018.09.001 Abstract: Capillary leak syndrome (CLS) is a rare and potentially life-threatening condition1 that may result in profound hypotension, generalized or segmental edema, hemoconcentration (elevated hematocrit), and hypoalbuminemia in the absence of albuminuria, findings that are virtually pathognomonic for the disease.2 CLS can be idiopathic3-5 or secondary to autoimmune diseases, malignant hematological diseases, viral infections, snakebites, and treatments such as chemotherapies and therapeutic growth factors.
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