Hsa-mir-144-3p expression is increased in umbilical cord serum of infants with atopic dermatitis

Atopic dermatitis (AD) is a common chronic inflammatory disease of childhood. Up to 60% of cases appear during the first year of life, and most resolve during the first few years.1 The skin of patients with AD is characterized by several abnormalities in barrier function, including altered lipid composition, decreased number of tight junctions, altered protease activity, and altered antimicrobial activity.2 The dual exposure to allergen hypothesis suggests that tolerance to antigens occurs in the neonate through high-dose oral exposure and allergen sensitization occurs through low-dose cutaneous exposure.