Alzheimer's disease is a degenerative disease and one of diseases that related to ageing and mostly happened with elderly people , and one of diseases that was has no determinant treatment , but now a days many new strategies have been discovered in the treatment of Alzheimer include drugs reduced amyloid peptide (AB) production , drugs prevent AB aggregation , drugs reduce inflammation associated with Alzheimer, cholinesterase inhibitor and N-methyl-d-aspartate ( NMDA ) antagonist like memantine, Indoleamine 2, 3-dioxygenase( IDO) inhibitor such as Coptisine which is a traditional Chinese medicinal prescription, and others some of it be approved in clinical trial and others still under investigation