Effects of Melatoninergic Antidepressant on the Brain Functional State in Patients with Post-Stroke Depression

Aim: This study focused on the Melitor (agomelatine) effects on the psychic-emotional activity, cerebral hemodynamic and bioelectrical activity of the brain in the patients with post-stroke depression. Patients: Thirty patients with post-stroke depression were treated with Melitor in the dose of 25 mg daily during two months. Results: Treated with Melitor, the study patients suffering from post-stroke depression showed positive drug effect on the psychic-emotional activity, improvement of cerebral hemodynamic and harmonization of the brain bioelectric activity. In the patients with right- versus left-hemispheric stroke, Melitor had more pronounced effect on the cerebral hemodynamic bioelectric activity of the brain. Owing to its multi modal action, the Melitor is recommended for the patients during their recovery after stroke in the sense of improving their functional and psychic-emotional state