Bilateral Ischemic Optic Neuropathy Following Intravenous Immunoglobulin

The purpose of this work is to report an association between intravenous immunoglobulin (IVIG) infusions and the development of bilateral ischemic optic neuropathy. A case report is described. A 76-year-old male receiving IVIG infusions developed loss of vision in the left eye and was diagnosed with ischemic optic neuropathy. Two months later, he developed another episode of ischemic optic neuropathy in the contralateral eye. The investigation for giant-cell arteritis, vasculopathy, and infiltrative processes was negative. The patient had minimal improvement in visual acuity over several months of follow-up. Bilateral ischemic optic neuropathy was likely caused by IVIG infusion in this case, given the temporal relationship and the negative workup for other risk factors