Management of Coats Disease Microaneurysms With Fundus Fluorescein Angiography

The purpose of this case series is to test the safety and efficacy of navigated laser in the treatment of microaneurysms in Coats disease. In a multicenter, retrospective case series, 10 individuals with active, leaking Coats-related microaneurysms in the macula were included. All participants were treated with the Navilas navigated laser (OD-OS, GmbH, Teltow, Germany) in a navigated treatment mode guided by fundus fluorescein angiography with a minimum of 4-month follow-up. Primary outcomes included central retinal thickness, best-corrected visual acuity, and microaneurysm closure rate. Mean age at navigated laser was 38.8 years (range, 14-61 years). Anatomic improvement or stabilization was noted in all participants (–10 μm), with stability within 10 letters of presenting visual acuity (±0.0 logarithm of the minimum angle of resolution [logMAR] [Snellen equivalent, 20/20]). No patient received any additional antivascular endothelial growth factor (anti-VEGF) treatment after the first navigated laser session. Patients could even discontinue previous anti-VEGF treatments. In this study, angiography-guided navigated laser treatment was a safe and effective treatment modality for Coats disease. The digital planning and navigated application of the laser seem to allow for good efficacy and a low complication rate