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3,3’-双(哌啶-1-甲基)八氢联萘酚的合成
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Abstract:
开发了一种通过类曼尼希反应制备3,3’-双(哌啶-1-甲基)八氢联萘酚简捷的一锅法合成方法。在溶剂甲醇中，使用廉价易得的哌啶盐酸盐替代管制品哌啶，以高达81.1%的收率得到3,3’-双(哌啶-1-甲基)八氢联萘酚。该法不仅反应条件温和，后处理操作简单，而且收率高。
A concise one-pot synthetic method was developed to prepare (S)-3,3’-bis(piperidin-1-ylmethyl)- octahydrobinaphthol (H8BINOL) by Mannich-type reaction. In the solvent methanol, (S)-3,3’-bis (piperidin-1-ylmethyl) octahydrobinaphthol was obtained in high yield of up to 81.1% using cheap and readily available piperidine hydrochloride to replace the controlled chemical piperidine.
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