应用血常规鉴别新型冠状病毒性肺炎的回顾性分析——血常规鉴别COVID-19
Blood Routine for Early Differential Diagnosis in COVID-19: A Retrospective Analysis—Blood Routine for COVID-19

DOI: 10.12677/ACREM.2019.74004, PP. 21-28

Keywords: 新型冠状病毒肺炎，血常规，早期诊断，鉴别诊断
Corona Virus Disease 2019 (COVID-19), Blood Routine, Early Diagnosis, Differential Diagnosis

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Abstract:

目的：探讨血常规在新型冠状病毒肺炎(COVID-19)鉴别诊断中的价值。方法：回顾性分析2020年1月23日至2020年2月10日兰州大学第一、第二医院确诊的15例COVID-19患者、11例疑似病例及同期住院的12例其他肺炎患者的血常规的差异，运用接受者操作特性曲线(receiver operating charac-teristic curve, ROC)的曲线下面积(AUC)评价其对COVID-19鉴别诊断的价值。结果：与疑似病例和其他肺炎患者相比，COVID-19患者早期白细胞计数降低、血小板分布宽度升高，存在显著性差异(P < 0.05)。ROC分析显示，白细胞计数对应AUC为0.87 (95% CI = 0.76~0.99)，血小板分布宽度对应的AUC为0.84 (95% CI = 0.70~0.99)。结论：基于有限的临床病例，血常规中白细胞计数下降、血小板分布宽度升高均对COVID-19患者的鉴别诊断具有参考价值，但此结论仍需大样本研究进一步证实。
Objective: To explore the value of blood routine and related indexes in the differential diagnosis of corona virus disease 2019 (COVID-19). Methods: A retrospective analysis of hospitalized patients diagnosed as COVID-19 (n = 15), suspected (n = 11) and other pneumonia (n = 12) during January 23, 2020 to February 10, 2020 were conducted. The data in blood routine test at initial visit were collected and compared. And the receiver operating characteristic (ROC) curve was used to evaluate the area under the curve (AUC) for differential diagnosis of COVID-19. Results: Compared with sus-pected cases and other pneumonia patients, early COVID-19 patients were associated with signifi-cantly reduced counts of white blood cell (WBC), increase counts of platelet distribution width (PDW) (P < 0.05). ROC analysis showed that the AUC of WBC was 0.87 (95% CI = 0.76~0.99), AUC of PDW was 0.84 (495% CI = 0.70~0.99). Conclusions: Based on limited number of cases, the reduction of WBC and the raise of PDW in blood routine is valuable for the differential diagnosis of COVID-19 patients, while the finding needs to be further confirmed by large sample studies.

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