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不同应激形式对新颖物体识别记忆提取的影响
Effects of Different Stress Forms on Novel Object Recognition Memory Retrieval

DOI: 10.12677/JPS.2019.74005, PP. 25-29

Keywords: 应激，记忆障碍，新颖物体识别
Stress, Memory Disorders, Novel Object Recognition

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Abstract:

目的：研究不同的应激形式对小鼠新颖物体识别记忆的影响。方法：将小鼠随机分成对照组，束缚应激组以及强迫游泳应激组，应激结束后30 min，3组小鼠进行新颖物体识别测试。结果：束缚应激组辨别指数显著低于对照组(p < 0.05)，强迫游泳应激组辨别指数与对照组无显著性差异，各组小鼠总探索时间、活动度均无显著性差异。结论：急性束缚应激损伤小鼠新颖物体识别记忆，而强迫游泳应激对新颖物体识别记忆没有影响。
Objective: To study the effects of different stress forms on novel object recognition and memory in mice. Methods: Mice were randomly divided into control group, restraint stress group and forced swimming stress group. Thirty minutes after the end of stress, three groups of mice were tested for novel object recognition. Results: The discrimination index of the restraint stress group was significantly lower than that of the control group (P < 0.05). The discrimination index of the forced swimming stress group was not significantly different from that of the control group. There was no significant difference in the total exploration time and activity of the mice in each group. Conclusion: Acute restraint stress damages novel object recognition and memory in mice, while forced swimming stress has no effect on novel object recognition memory.

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