Novel coronavirus is threatening the health of people all over the world and all possible treatment strategies are in urgent. The sensitive of virus to heat proposed temperature treatment as an effective method against coronavirus. Here, we proposed several non-drug therapies including far-infrared, thermal air, thermal oxygen, ozone, hydrogen therapy and plasma physical therapy for immediate clinical trial and implementation. Compared with the drug therapy, these methods are safe without side effects, the highest benefit-to-risk ratio, user-friendly, and low implementation costs. It is urgent and significant to start these non-drug therapeutic design and implementation as early as possible, to determine the safety and effectiveness of these therapeutic methods.
References
[1]
Wu, J.T., Leung, K., Bushman, M., et al. (2020) Estimating Clinical Severity of COVID-19 from the Transmission Dynamics in Wuhan, China. Nature Medicine, 26, 506-510. https://doi.org/10.1038/s41591-020-0822-7
[2]
Prussin, A.J., Schwake, D.O., Lin, K., et al. (2018) Survival of the Enveloped Virus Phi6 in Droplets as a Function of Relative Humidity, Absolute Humidity, and Temperature. Applied and Environment Microbiology, 84, 1-18. https://doi.org/10.1128/AEM.00551-18
[3]
Shao, L., Pang, N., Yan, P., et al. (2018) Control of Body Temperature and Immune Function in Patients Undergoing Open Surgery for Gastric Cancer. Bosnian Journal of Basic Medical Sciences, 18, 289-296. https://doi.org/10.17305/bjbms.2018.2552
[4]
Wang, S.G. Ventilator. Chinese Invention Patent, No. 202010147295.0. (Pending Patent)
[5]
Fabiola, A., Francesco, M.I., Mariateresa, C., et al. (2020) Hyperbaric Oxygen Therapy in Fibromyalgia and the Diseases Involving the Central Nervous System. Clinical and Experimental Rheumatology, 38, 94-98.
[6]
Wu, Y., Yuan, M., Song, J.B., et al. (2019) Hydrogen Gas from Inflammation Treatment to Cancer Therapy. ACS Nano, 13, 8505-8511. https://doi.org/10.1021/acsnano.9b05124
[7]
Wang, S.G. Treatment Cabin and Method of Use. Chinese Invention Patent, No. 202010149180.5. (Pending Patent)
[8]
Kominami, K., Noda, K., Takahashi, N., et al. (2020) Cardiovascular Reactions for Whole-Body Thermal Therapy with a Hot Pack and Waon Therapy. International Journal of Hyperthermia, 37, 184-191. https://doi.org/10.1080/02656736.2020.1723719
[9]
Yu, S., Chiu, J., Yang, S., et al. (2006) Biological Effect of Far-Infrared Therapy on Increasing Skin Microcirculation in Rats. Photodermatology, Photoimmunology & Photomedicine, 22, 78-86. https://doi.org/10.1111/j.1600-0781.2006.00208.x
[10]
Chang, Y. (2018) The Effect of Far Infrared Radiation Therapy on Inflammation Regulation in Lipopolysaccharide-Induced Peritonitis in Mice. SAGE Open Medicine, 6, 1-7. https://doi.org/10.1177/2050312118798941
[11]
Kim, S., Park, H.T., Soh, S.H., et al. (2019) Evaluation of the Immunobiological Effects of a Regenerative Far-Infrared Heating System in Pigs. Journal of Veterinary Science, 20, e61. https://doi.org/10.4142/jvs.2019.20.e61
[12]
Wu, X.Q., Wang, S.G. and Han, L. (2005) Sterilizing Effect of Atmospheric Pressure Plasma Jet on Microbes. Acta Microbiologica Sinica, 45, 312-314.
[13]
Xia, T., Kleinheksel, A., Lee, E.M., et al. (2019) Inactivation of Airborne Viruses Using a Packed Bed Non-Thermal Plasma Reactor. Journal of Physics D: Applied Physics, 52, Article ID: 255201. https://doi.org/10.1088/1361-6463/ab1466
[14]
Liao, X., Liu, D., Xiang, Q., et al. (2017) Inactivation Mechanisms of Non-Thermal Plasma on Microbes: A Review. Food Control, 75, 83-91. https://doi.org/10.1016/j.foodcont.2016.12.021
[15]
Reitberger, H., Martines, E., Mohr, A., et al. (2018) Cold Plasma to Treat Therapy-Refractive Corneal Ulcers. Klinische Monatsblatter für Augenheilkunde, 235, 1366-1370. https://doi.org/10.1055/a-0792-1301
[16]
Nguyen, L., Lu, P., Boehm, D., et al. (2018) Cold Atmospheric Plasma Is a Viable Solution for Treating Orthopaedic Infection: A Review. Biology Chemistry, 400, 77-86. https://doi.org/10.1515/hsz-2018-0235
[17]
Sönnergren, H.H., Strömbeck, L. and Faergemann, J. (2012) Antimicrobial Effects of Plasma-Mediated Bipolar Radiofrequency Ablation on Bacteria and Fungi Relevant for Wound Infection. Acta Dermato Venereologica, 92, 29-33. https://doi.org/10.2340/00015555-1171
[18]
Wang, S.G. (2017) Plasma Device with a Replaceable (Plug-In) Discharge Tube. PCT/CN 2015000023, Authorized by Japan, Russia, Australian with No. 6535746, No. 2656333, No. 2015376829.